Clinical Trials

Some of the most important clinical trials ever completed in radiation oncology have been led by UCSF investigators, from cancers of the brain and spine (central nervous system), to cancers of the head and neck, to cancers of the prostate. Numerous UCSF led studies on central nervous system tumors have examined optimal drugs, radiation type (brachytherapy or gamma-knife), and the use of hyperthermia (heat). The largest randomized trial ever completed studying optimal fractionation schemes for head and neck cancer was designed and chaired by Karen Fu, ASTRO (American Society for Radiation Oncology) Gold Medal winner, from UCSF. The largest prostate cancer trial completed to date, evaluating the impact of radiation field on outcomes, was designed and chaired by an investigator from UCSF. As a leading research institution, UCSF fields numerous clinical trials in many areas simultaneously. Here is more information on clinical trials and current open studies:

Contact for UCSF Radiation Oncology clinical trials:
Arla Yost, MSc, CCRP
Email: Arla.Yost@ucsf.eduPancreatic Cancer
Phone: 415-514-9603Pancreatic Cancer

Current Trials

Principal Investigator	Study Title	Disease	Status
Mary Feng	RTOG 1112 Randomized Phase III Study of Sorafenib Versus Stereotactic Body Radiation Therapy Followed by Sorafenib in Hepatocellular Carcinoma.	Liver Cancer	Open
Mekhail Anwar	mFFX-Pancreas - 164516 Pancreatic Cancer Radiotherapy Study Group (PanCRS) Trial: A Randomized Phase III Study Evaluating Modified FOLFIRINOX (mFFX) with or without Stereotactic Body Radiotherapy (SBRT) in the Treatment of Locally Advanced Pancreatic Cancer	Pancreatic Cancer	Open
I-Chow Joe Hsu	BSD2000 Hyperthermia using the BSD2000 for the Treatment of Patients With Advanced Tumors of the Pelvis.	Tumors of the Pelvis	Open
Sue Yom	VISMO-122011 A Phase ll study of Radiation Therapy and Vismodegib, for the Treatment of Locally Advanced Basal Cell Carcinoma of the Head and Neck.	Head & Neck Cancer	Open
Sue Yom	NRG-HN001 Randomized Phase II and Phase III Studies of Individualized Treatment for Nasopharyngeal Carcinoma Based on Biomarker Epstein Barr Virus (EBV) Deoxyribonucleic Acid (DNA).	Head & Neck Cancer	Open
Sue Yom	NRG-HN002 A Randomized Phase II Trial for Patients with p16 Positive, Non-Smoking Associated, Locoregionally Advanced Oropharyngeal Cancer.	Head & Neck Cancer	Open
Sue Yom	NCCN Acceptability and Effectiveness of a Novel Internet-Based Decision-Making Aid Based on the NCCN Non-Small Cell Lung Cancer Patient Guidelines.	Lung Cancer	Open
Mack Roach Alexander Gottschalk, I-Chow Joe Hsu	RTOG 0924 Androgen Deprivation Therapy and High Dose Radiotherapy With or Without Whole-Pelvic Radiotherapy in Unfavorable Intermediate or Favorable High Risk Prostate Cancer: A Phase III Randomized Trial.	Prostate Cancer	Open
Albert Chang	Enzalutamide-Prostate - 15558 Phase II Multi-Institutional Trial of Dose Escalated Radiotherapy with Leuprolide and Enzalutamide in Patients with Very High Risk Prostate Cancer	Prostate Cancer	Open
Albert Chang	Choline-Prostate - 15551 Phase I Feasibility Study of Accelerated Hypofractionated Whole Pelvic Radiotherapy for Patients with Intermediate-High Risk Prostate Cancer	Prostate Cancer	Open

For more information about clinical trials: http://www.clinicaltrials.gov/ct/info/whatis#whatis