David Raleigh, MD, PhD

PGY3

 

Area of interest:

Stereotactic radiation, Brachytherapy, Radioimmunotherapy

Educational Background

Radiation Oncology Residency, University of California San Francisco (2013-2017)

Preliminary Medicine Internship, Kaiser Permanente Santa Clara Medical Center, Santa Clara (2012-2013)

M.D., University of Chicago (2012)

Ph.D., Department of Pathology, University of Chicago (2010)

B.S., Molecular and Cell Biology, University of California, Berkeley (2004)

B.S., Cognitive Science, University of California, Berkeley (2004)

Awards & Honors

Teaching Award in Recognition of Excellent Medical Student Education, Kaiser Permanente Santa Clara Medical Center, Santa Clara (2013)

Department Award for Outstanding Performance in the General Field of Radiation and Cellular Oncology, University of Chicago, Chicago (2012)

Naomi Ragins Goldsmith Career Development Award, University of Chicago, Medical Scientist Training Program, Chicago (2011)

Top Quartile in Graduating Class of 2012, University of Chicago, Pritzker School of Medicine, Chicago (2011)

Takeda Travel Award, Experimental Biology, Anaheim (2010)

Outstanding Graduate Student Oral Presentation, University of Chicago Biomedical Sciences Cluster Retreat (2009)

DDW Poster of Distinction, Digestive Disease Week, Chicago (2009)

FASEB Travel Award, FASEB Gastrointestinal Tract XIII, Snowmass (2009)

Trainee, National Institutes of Health Medical Scientist Training Program (2005-2012)

Graduation with High Honors, Department of Cognitive Science, University of California, Berkeley (2004)

Graduation with High Honors, Department of Molecular Cell Biology, University of California, Berkeley (2004)

College of Letter’s and Science Dean’s Honor Roll, University of California, Berkeley (2001-2004)

Selected Publications and Abstracts

Original Peer Reviewed Articles

Raleigh DR, Marchiando AM, Zhang Y, Shen L, Sasaki H, Wang Y, Long M, Turner JR. Tight junction-associated MARVEL proteins marvelD3, tricellulin, and occludin have distinct but overlapping functions. Mol Biol Cell. 2010; 21: 1200-1213. Featured article and cover art.

Weber CR, Raleigh DR, Su L, Shen L, Sullivan EA, Wang Y, Turner JR. Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression toalter tight junction ion selectivity. J Biol Chem. 2010; 285: 12037-12046.

Marchiando AM, Shen L, Graham WV, Weber CR, Schwarz BT, Austin JR, Raleigh DR, Guan Y, Watson Alastair JM, Montrose MH, Turner JR. Caveolin-1-dependentoccludin endocytosis is required for TNF-induced tight junction regulation in vivo. J Cell Biol. 2010; 189: 111-126. Featured article and cover art.

Yu D, Marchiando AM, Weber CR, Raleigh DR, Wang Y, Shen L, Turner JR. MLCK regulates tight junction barrier function via the ZO-1 actin binding region: In vitro, in vivo, and in silico analysis. Proc Natl Acad Sci USA. 2010. 107: 8237-8241.

Raleigh DR, Boe DM, Yu D, Weber CR, Marchiando AM, Bradford EM, Wang Y, Wu L, Schneeberger EE, Shen L, Turner JR. Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function. J Cell Biol. 2011. 193: 565-582.

Schmitt AM, Crawley CD, Kang S, Raleigh DR, Yu X, Wahlstrom JS, Voce DJ, Darga TE, Weichselbaum RR, Yamini B.p50 (NF-kB1) is a novel effector protein in the cytotoxic response to DNA methylation damage. Mol Cell. 2011. 44: 785-796.

Bejarano F, Bortolamiol-Becet D, Dai Q, Sun K, Saj A, Chou Y, Raleigh DR, Kim K, Ni J, Duan H, Yang J, Fulga TA, Vactor DV, Perrimon N, Lai EC. A genomewide transgenic resource for conditional expression of Drosophila microRNAs. Development. 2012. 139: 2821-2831. Featured article and cover art.

Golden DW, Raleigh DR, Chmura SJ, Koshy M, Howard AR. The Radiation Oncology Fourth-Year Medical Student Clerkship: A Targeted Needs Assessment. Int J Radiat Oncol Biol Phys. 2013. 85: 296-297.

Crawley CD, Raleigh DR, Kang S, Voce DJ, Schmitt AM, Weichselbaum RR, Yamini B. DNA damage-induced cytotoxicity is mediated by the cooperative interaction of phospho-NF-kB and a single nucleotide in the kB-site. Nucl Acids Res. 2013. 41: 764-774.

Buschmann MM, Shen L, Rajapakse H, Raleigh DR, Wang Y, Wang Y, Lingaraju A, Zha J, Abbott E, McAuley E, Breskin LA, Wu L, Anderson K, Turner JR, Weber CR. Occludin OCEL domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux. Molecular Biology of the Cell (under revision)

Reviews and Editorials

Raleigh DR. Mind the gap. Lab Invest. 2006; 86: 979-980.

Shen L, Weber CR, Raleigh DR, Turner JR. Tight junction pore and leak pathways: A dynamic duo. Annu Rev Phys. 2011; 73: 283-309. Raleigh DR, Haas-Kogan DA. Molecular targets and mechanisms of radiosensitization within DNA damage response pathways. Future Oncol. 2013. 9: 219-233.

Abstracts

Weber CR, Raleigh DR, Wang Y, Turner JR. Interleukin 13 (IL-13) and Tumor Necrosis Factor (TNF) Affect Distinct Components of the Tight Junction Barrier By Differing Mechanisms. Digestive Disease Week. 2009: Chicago, IL.

Raleigh DR, Zhang Y, Marchiando AM, Wang Y, Shen L, Long M, Turner JR. TAMPs: A Tight Junction Protein Family with Non-Redundant Functions. Digestive Disease Week. 2009: Chicago, IL.

Weber CR, Raleigh DR, Su L, Shen L, Sullivan EA, Wang Y, Turner JR. Constitutively active myosin light chain kinase induces immune activation and cytoskeleton-independent tight junction dysregulation. FASEB: Gastrointestinal Tract XIII. 2009: Snow Mass, CO.

Raleigh DR, Marchiando AM, Zhang Y, Shen L, Wang Y, Long M, Turner JR. The novel protein marvelD3 completes the tight junction-associated MARVEL protein (TAMP) family. FASEB: Gastrointestinal Tract XIII. 2009: Snow Mass, CO.

Raleigh DR, Marchiando AM, Boe D, Wang Y, Shen L, Turner JR. Casein kinase 2 (CK2) phosphorylates occludin at Ser408 to increase intra-tight junction diffusion and reduce paracellular barrier function. FASEB J. 2010; 24:1004.6.

Schmitt AM, Yu X, Kang S, Raleigh DR, Dolan ME, Weichselbaum RR, Yamini B. NF-kB1-p50 is a novel mediator of methylation-induced apoptosis. American Association of Cancer Research. 2010: Washington, DC.

Crawley CD, Schmitt AM, Kang S, Raleigh DR, Weichselbaum RR, Yamini B. p50 (NF-kB1) is a novel effector protein in the cytotoxic response to DNA methylation damage. Keystone Symposia: NF-kappaB Signaling and Biology, From Bench to Bedside. 2012: Whistler, British Columbia.

Kang S, Crawley CD, Schmitt AM, Raleigh DR, Weichselbaum R, Yamini B. O6-methylguandine:deoxythymidine mismatches sensitize cells to DNA strand break-induced cytotoxicity. American Association of Cancer Research. 2012: Chicago, IL.

Raleigh DR, Crawley CD, Kang S, Schmitt AM, Yamini B. Functional interaction between phospho-p50 and the kB-site mediates cytotoxicity in response to DNA methylation damage. Keystone Symposia: NF-kappaB Signaling and Biology, From Bench to Bedside. 2012: Whistler, British Columbia.

Golden DW, Raleigh DR, Suracu M, Farrey K, Chmura SJ. Linear-accelerator based stereotactic radiosurgery outcomes for melanoma and renal cell carcinoma brain metastases. American Society for Radiation Oncology Annual Meeting. 2012: Boston, MA.

Golden DW, Raleigh DR, Chmura SJ, Koshy M, Howard AR. The Radiation Oncology Fourth-Year Medical Student Clerkship: A Targeted Needs Assessment. American Society for Radiation Oncology Annual Meeting. 2012: Boston, MA.