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• About

Professional Focus

Dr. Igor J. Barani is a radiation oncologist with a clinical interest in the treatment of central nervous system malignancies.  He specializes in the use use of radiosurgical treatment techniques, such as the Gamma Knife and Cyberknife, and modern radiotherapy techniques, such as intensity-modulated radiotherapy (IMRT) and proton radiotherapy to treat a variety of malignant and benign conditions.  Dr. Barani is specifically interested in the development and implementation of innovative, multi-modality translational protocols to treat adult and pediatric patients with brain tumors, particularly with respect to improving tumor control outcomes and preservation of neurologic/neurocognitive function.  His basic science interests revolve around neural stem cells and their potential roles in gliomagenesis as well as post-treatment neurocognitive decline.  Dr. Barani hopes to use the understanding of neural stem cell biology and modern treatment techniques to create meaningful translational studies that will result in more, healthier survivors of central nervous system tumors.

Education

Professional Experience

Awards & Honors

Publications

Barani IJ, Hsu NH, Kreutzer JC, Broaddus WC, Anscher MS. A Study of Neural Stem Cell (NSC) Preserving Whole Brain Radiotherapy (WBRT) and Stereotactic Radiosurgery in Patients with 1-6 Brain Metastases.  Phase I/II trial, Virginia Commonwealth University, Richmond, VA. [Open Protocol]

Barani IJ, Benedict SH, Lin PS. Neural Stem Cells: Implications for the Conventional Radiotherapy of Central Nervous System Malignancies. Int J Radiat Oncol Biol Phys 68:324–333; 2007.

Barani IJ, Cuttino LW, Benedict SH, Todor D, Bump EA, Wu Y, Chung TD, Broaddus WC. Lin PS. Neural Stem Cell-Preserving External-Beam Radiotherapy of Central Nervous System Malignancies. Int J Radiat Oncol Biol Phys 68:978–985; 2007.

Yakovlev VA, Barani IJ, Rabender CS, Black SM, Leach JK, Mikkelsen RB. Tyrosine Nitration of I-κB: A Novel Mechanism for NF-κB Activation, Biochemistry. 2007 Oct 23;46(42):11671-83.

Kusnetzow A, Singh DL, Martin CH, Barani IJ, Birge RR.  Nature of the chromophore binding site of bacteriorhodopsin: the potential role of Arg82 as a principal counterion.  Biophys J. 1999 May; 76(5):2370-89.