• Publications
• Experience
• About

Professional Focus

Dr. Igor J. Barani is a radiation oncologist with a clinical interest in the treatment of central nervous system malignancies.  He specializes in the use of radiosurgical treatment techniques, such as the Gamma Knife and Cyberknife, and modern radiotherapy techniques, such as intensity-modulated radiotherapy (IMRT) and proton radiotherapy to treat a variety of malignant and benign conditions.  Dr. Barani is specifically interested in the development and implementation of innovative, multi-modality translational protocols to treat adult and pediatric patients with brain tumors, particularly with respect to improving tumor control outcomes and preservation of neurologic/neurocognitive function.  His basic science interests revolve around neural stem cells and their potential roles in gliomagenesis as well as post-treatment neurocognitive decline.  Dr. Barani hopes to use the understanding of neural stem cell biology and modern treatment techniques to create meaningful translational studies that will result in more, healthier survivors of central nervous system tumors.

Education

1994-1998	College of Arts & Sciences, Syracuse University, Syracuse, NY	BS	Chemistry
2000-2001	Howard Hughes Medical Institute, National Institutes of Health, Bethesda, MD	Research Fellow	Biophysics
1998-2003	College of Medicine, SUNY Upstate Medical University, Syracuse, NY	MD	Medicine
2003-2004	Yale-New Haven Medical Center, Hospital of St. Raphael, New Haven, CT	Intern	Internal Medicine
2004-2008	College of Medicine, Virginia Commonwealth University, Richmond, VA	Resident	Radiation Oncology

Professional Experience

2008-Present

UCSF

Assistant Professor

Awards & Honors

1995-1998	Honors Program at Syracuse University
1995	L.T. Adolph Ornstein Scholar
1996	Chancellor’s Scholar
1996	Golden Key National Honor Society
1996	Phi Eta Sigma National Honor Society
1996	Willem Prins Award for Exceptional Performance in Physical Chemistry
1997	Merck Chemistry Award for Overall Academic Performance
1997	Pfizer Undergraduate Research Fellow
1997	American Institute of Chemists Award
1997	Senator Goldwater National Scholar
1998	Syracuse University Scholar
2000	Letter of Commendation for Exceptional Performance in a Medicine Clerkship
2000	Research to Prevent Blindness Research Grant, Awardee
2000	Howard Hughes Medical Institute, Research Scholar at the National Institutes of Health
2001	Howard Hughes Medical Institute, Continued Support for Completion of Medical Studies
2004	Intern-of-the-Year, Hospital of St. Raphael/Yale-New Haven Medical Center
2005	American Board of Radiology (ABR) Holman Research Pathway in Radiation Oncology
2005	American Society for Therapeutic Radiology and Oncology (ASTRO) Resident/Fellow Seed Grant
2006-2007	Radiological Society of North America (RSNA) Röentgen Resident Research Award

Recent Significant Publications

Bloch O, Sun M, Kaur G, Barani IJ, Parsa AT. Fractionated radiotherapy for optic nerve sheath meningiomas. J Clin Neurosci. 2012 Jun 22.

Mills SA, Oh MC, Rutkowski MJ, Sughrue ME, Barani IJ, Parsa AT. Supratentorial hemangioblastoma: clinical features, prognosis, and predictive value of location for von Hippel-Lindau disease. Neuro Oncol. 2012 Jun 21. 

Han SJ, Oh MC, Sughrue ME, Rutkowski MJ, Aranda D, Barani IJ, Parsa AT. The effect of the 2003 Consensus Reporting Standards on Publications describing patients with vestibular schwannoma treated with stereotactic radiosurgery. J Clin Neurosci. 2012 Aug;19(8):1144-7.

Descovich M, Ma L, Chuang CF, Larson DA, Barani IJ. Comparison between prone and supine patient setup for spine stereotactic body radiosurgery. Technol Cancer Res Treat. 2012 Jun;11(3):229-36.

Caballero JA, Sneed PK, Lamborn KR, Ma L, Denduluri S, Nakamura JL, Barani IJ, McDermott MW. Prognostic Factors for Survival in Patients Treated With Stereotactic Radiosurgery for Recurrent Brain Metastases After Prior Whole Brain Radiotherapy. Int J Radiat Oncol Biol Phys. 2011 Nov 11

Ma L, Lee L, Barani I, Hwang A, Fogh S, Nakamura J, McDermott M, Sneed P, Larson DA, Sahgal A. Shot sequencing based on biological equivalent dose considerations for multiple isocenter Gamma Knife radiosurgery. Phys Med Biol. 2011 Nov 21;56(22):7247-56. Epub 2011 Oct 28.

Bloch O, Kaur G, Jian BJ, Parsa AT, Barani IJ. Stereotactic radiosurgery for benign meningiomas. J Neurooncol. 2011 Oct 18.

Lupo JM, Chuang CF, Chang SM, Barani IJ, Jimenez B, Hess CP, Nelson SJ. 7-Tesla Susceptibility-Weighted Imaging to Assess the Effects of Radiotherapy on Normal-Appearing Brain in Patients with Glioma. Int J Radiat Oncol Biol Phys. 2011 Oct 12.

Kirby N, Chuang C, Pouliot J, Hwang A, Barani IJ. Physics strategies for sparing neural stem cells during whole-brain radiation treatments. Med Phys. 2011 Oct;38(10):5338-44.

Rutkowski MJ, Bloch O, Jian BJ, Chen C, Sughrue ME, Tihan T, Barani IJ, Berger MS, McDermott MW, Parsa AT. Management of recurrent intracranial hemangiopericytoma. J Clin Neurosci. 2011 Nov;18(11):1500-4. Epub 2011 Sep 13.

Rutkowski MJ, Jian BJ, Bloch O, Chen C, Sughrue ME, Tihan T, Barani IJ, Berger MS, McDermott MW, Parsa AT. Intracranial hemangiopericytoma: Clinical experience and treatment considerations in a modern series of 40 adult patients. Cancer. 2011 Aug 11. doi: 10.1002/cncr.26411.

Ma L, Sahgal A, Hwang A, Hu W, Descovich M, Chuang C, Barani I, Sneed PK, McDermott M, Larson DA. A two-step optimization method for improving multiple brain lesion treatments with robotic radiosurgery. Technol Cancer Res Treat. 2011 Aug;10(4):331-8.

Tate M, Sughrue ME, Rutkowski MJ, Kane AJ, Aranda D, McClinton L, McClinton L, Barani IJ, Parsa AT. The long-term postsurgical prognosis of patients with pineoblastoma. Cancer. 2011 Jun 29. doi: 10.1002/cncr.26300.

Todor DA, Barani IJ, Lin PS, Anscher MS. Moving toward focal therapy in prostate cancer: dual-isotope permanent seed implants as a possible solution. Int J Radiat Oncol Biol Phys. 2011 Sep 1;81(1):297-304. Epub 2011 Apr 30.

Sughrue ME, Choi J, Rutkowski MJ, Aranda D, Kane AJ, Barani IJ, Parsa AT. Clinical features and post-surgical outcome of patients with astroblastoma. J Clin Neurosci. 2011 Jun;18(6):750-4. Epub 2011 Apr 19.

Ma L, Petti P, Wang B, Descovich M, Chuang C, Barani IJ, Kunwar S, Shrieve DC, Sahgal A, Larson DA. Apparatus dependence of normal brain tissue dose in stereotactic radiosurgery for multiple brain metastases. J Neurosurg. 2011 Jun;114(6):1580-4. Epub 2011 Mar 4.

Dasgupta T, Barani IJ, Roach M 3rd. Successful radiation treatment of anaplastic thyroid carcinoma metastatic to the right cardiac atrium and ventricle in a pacemaker-dependent patient. Radiat Oncol. 2011 Feb 14;6:16.

Descovich M, Sneed PK, Barbaro NM, McDermott MW, Chuang CF, Barani IJ, Nakamura JL, Lijun M. A dosimetric comparison between Gamma Knife and CyberKnife treatment plans for trigeminal neuralgia. J Neurosurg. 2010 Dec;113 Suppl:199-206.

Ivan ME, Sughrue ME, Clark AJ, Kane AJ, Aranda D, Barani IJ, Parsa AT. A meta-analysis of tumor control rates and treatment-related morbidity for patients with glomus jugulare tumors. J Neurosurg. 2011 May;114(5):1299-305. Epub 2010 Oct 29.

Sughrue ME, Yang I, Kane AJ, Fang S, Clark AJ, Aranda D, Barani IJ, Parsa AT. Endocrinologic, neurologic, and visual morbidity after treatment for craniopharyngioma. J Neurooncol. 2011 Feb;101(3):463-76. Epub 2010 Jun 10.

Sahgal A, Barani IJ, Novotny J Jr, Zhang B, Petti P, Larson DA, Ma L. Prescription dose guideline based on physical criterion for multiple metastatic brain tumors treated with stereotactic radiosurgery. Int J Radiat Oncol Biol Phys. 2010 Oct 1;78(2):605-8. Epub 2010 May 14.

Sughrue ME, Rutkowski MJ, Aranda D, Barani IJ, McDermott MW, Parsa AT. Factors affecting outcome following treatment of patients with cavernous sinus meningiomas. J Neurosurg. 2010 Nov;113(5):1087-92. Epub 2010 May 7.

Sughrue ME, Rutkowski MJ, Aranda D, Barani IJ, McDermott MW, Parsa AT. Treatment decision making based on the published natural history and growth rate of small meningiomas. J Neurosurg. 2010 Nov;113(5):1036-42. Epub 2010 Apr 30.

Yang I, Sughrue ME, Rutkowski MJ, Kaur R, Ivan ME, Aranda D, Barani IJ, Parsa AT. Craniopharyngioma: a comparison of tumor control with various treatment strategies. Neurosurg Focus. 2010 Apr;28(4):E5.

Rutkowski MJ, Sughrue ME, Kane AJ, Aranda D, Mills SA, Barani IJ, Parsa AT. Predictors of mortality following treatment of intracranial hemangiopericytoma. J Neurosurg. 2010 Aug;113(2):333-9.

Kane AJ, Sughrue ME, Rutkowski MJ, Aranda D, Mills SA, Buencamino R, Fang S, Barani IJ, Parsa AT. Posttreatment prognosis of patients with esthesioneuroblastoma. J Neurosurg. 2010 Aug;113(2):340-51.

Fatyga M, Williamson JF, Dogan N, Todor D, Siebers JV, George R, Barani I, Hagan M. A comparison of HDR brachytherapy and IMRT techniques for dose escalation in prostate cancer: a radiobiological modeling study. Med Phys. 2009 Sep;36(9):3995-4006.

Bauman GS, Shaw EG, Cha S, Barani IJ, McDermott M. Some like it hot...and others not! Int J Radiat Oncol Biol Phys. 2009 Aug 1;74(5):1319-22.

Yakovlev VA, Barani IJ, Rabender CS, Black SM, Leach JK, Graves PR, Kellogg GE, Mikkelsen RB. Tyrosine nitration of IkappaBalpha: a novel mechanism for NF-kappaB activation. Biochemistry. 2007 Oct 23;46(42):11671-83. Epub 2007 Oct 2.

Barani IJ, Benedict SH, Lin PS. Neural Stem Cells: Implications for the Conventional Radiotherapy of Central Nervous System Malignancies. Int J Radiat Oncol Biol Phys 68:324–333; 2007.

Barani IJ, Cuttino LW, Benedict SH, Todor D, Bump EA, Wu Y, Chung TD, Broaddus WC. Lin PS. Neural Stem Cell-Preserving External-Beam Radiotherapy of Central Nervous System Malignancies. Int J Radiat Oncol Biol Phys 68:978–985; 2007.

Yakovlev VA, Barani IJ, Rabender CS, Black SM, Leach JK, Mikkelsen RB. Tyrosine Nitration of I-κB: A Novel Mechanism for NF-κB Activation, Biochemistry. 2007 Oct 23;46(42):11671-83.

 

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