• Publications
• Experience
• About

Professional Focus

Dr. Huang's clinical interests include treating central nervous system and pediatric malignancies, as well as lung, gastrointestinal and head and neck cancer. She is especially interested in using modern radiotherapy techniques and devices such as intensity modulated radiotherapy (IMRT), intraoperative radiotherapy (IORT), Gamma Knife, Cyberknife and proton beam radiotherapy to treat a variety of malignant and benign conditions.

Her main research interests include outcome studies, which evaluate the efficacy as well as toxicities of modern radiotherapy techniques. She reviewed clinical results of treating oropharyngeal cancer and thyroid cancer patients using IMRT, as well as patients with brain metastases who were treated with I-125 permanent seeds implantation after surgical resection. Her current focus is in the area of Cyberknife radiosurgery. Ongoing research includes reviewing results of patients with lung, head and neck and other cancers treated with Cyberknife radiosurgery at UCSF. The other areas of research include dosimetric comparisons of modalities such as IMRT or high dose rate (HDR) brachytherapy versus Cyberknife, which provide guidance in the clinical decision making process of choosing a specific modality. More importantly, efforts are devoted to developing prospective clinical research protocols in the treatment of primary lung cancer, lung metastases, hepatocellular carcinoma, liver metastases, extrahepatic biliary tract cancer, pancreatic cancer and prostate cancer.

Education

Professional Experience

Awards & Honors

Publications

Shores EW, Huang K, Tran T, Lee E, Grinberg A, Love PE. Role of TCR zeta chain in T cell development and selection. Science 1994;266:1047-1050.

Sommers CL, Huang K, Shores EW, Grinberg A, Charlick DA, Kozak CA, Love PE. Murine txk: a protein tyrosine kinase gene regulated by T cell activation. Oncogene 1995;11:245-251.

Huang K, Sommers CL, Grinberg A, Kozak CA, Love PE. Cloning and characterization of PTP-K1, a novel nonreceptor protein tyrosine phosphatase highly expressed in bone marrow. Oncogene 1996;13:1567-1573.

Flamand V, Shores EW, Tran T, Huang K, Lee E, Grinberg A, Kinet JP, Love PE. Delayed maturation of CD4- CD8- Fc gamma RII/III+ T and natural killer cell precursors in Fc epsilon RI gamma transgenic mice. J Exp Med 1996;184:1725-1735.

Cao Z, Huang K, Horwitz AF. Identification of a domain on the integrin alpha5 subunit implicated in cell spreading and signaling. J Biol Chem 1998;273:31670-31679.

DeJarnette JB, Sommers CL, Huang K, Woodside KJ, Emmons R, Katz K, Shores EW, Love PE. Specific requirement for CD3epsilon in T cell development. Proc Natl Acad Sci USA 1998;95:14909-14914.

Huang K, Vaughn DJ, Shaw LM, Recio A, Bonner HS, Haller DG. A phase II trial and pharmacokinetic analysis of 96-hour infusional paclitaxel in patients with metastatic colorectal cancer. Am J Clin Oncol 1998;21:548-552.

Sommers CL, Dejarnette JB, Huang K, Lee J, El-Khoury D, Shores EW, Love PE. Function of CD3 epsilon-mediated signals in T cell development. J Exp Med 2000;192:913-919.

Azzam HS, DeJarnette JB, Huang K, Emmons R, Park CS, Sommers CL, El-Khoury D, Shores EW, Love PE. Fine tuning of TCR signaling by CD5. J Immunol 2001;166:5464-5472.

Huang K, Haas-Kogan D, Weinberg V, Krieg R. Higher radiation dose with shorter treatment duration improves outcome for locally advanced carcinoma of anal canal. World J Gastroenterol 2007;13:895-900

Sahgal A, Chou D, Ames C, Ma L, Lamborn K, Huang K, Chuang C, Aiken A, Petti P, Weinstein P, Larson D.  Image-Guided Robotic Stereotactic Body Radiosurgery for Benign Spinal Tumors: The University of California San Francisco Preliminary Experience. Technol Cancer Res Treat. 2007;6(6):595-604.

Chuang C, Sahgal A, Lee L, Larson D, Huang K, Petti P, Verhey L, Ma L. Effects of residual target motion for image-tracked spine radiosurgery. Med Phys. 2007;34(11):4484-90.

Ma L, Chuang C, Huang K, Petti P, Sahgal A, Larson D, Verhey L. Pretreatment Quality Assurance of Imaging-tracked Lung Tumor Treatments. Journal of Physics: Conference Series 2007.

Kased N, Huang K, Nakamura JL, Saghal A, Larson DA, McDermott MW, Sneed PK.  Gamma Knife radiosurgery for brainstem metastases: the UCSF experience. J Neurooncol 2008;86:195-205.

Sahgal A, Chuang C, Larson D, Huang K, Petti P, Weinstein P, Ma L. Split-volume treatment planning of multiple consecutive vertebral body metastases for CyberKnife image guided robotic radiosurgery. Medical Dosimetry 2008;33:175-179.

Huang K, Xia P, Chuang C, Weinberg V, Glastonbury C, Kramer A, Eisele DW, Lee NY, Yom SS, Phillips, TL and Quivey, JM.  Intensity-Modulated Chemoradiation for Treatment of Stage III and IV Oropharyngeal Carcinoma: The University of California-San Francisco Experience. Cancer 2008;113:497-507.

Huang K, Sneed PK, Kunwar S, Kragen A, Larson DA, Berger MS, Chan A, Pouliot J, McDermott MW. Surgical resection and permanent iodine-125 brachytherapy for brain metastasis. In press, J. Neurooncol.

Ma L, Verhey L, Chuang C, Descovich M, Smith V, Huang K, McDermott M, Sneed P.  Effect of Sector Collimation on Average Dose Fall-off for Gamma Knife Perfexion. In press, J Neurosurgery.

BOOKS AND CHAPTERSSahgal A, Ames C, Chou D, Ma L, Huang K, Xu W, Chin C, Weinberg V, Chuang C, Weinstein P, Larson D.  Stereotactic Body Radiosurgery is Effective Salvage Therapy for Patients with Prior Radiation for Spinous Metastases. In press, IJROBP

Sneed PK, Huang K, Rubenstein JL. Brain metastases and carcinomatous meningitis. In: Abeloff MD, Armitage JO, Niederhuber JE, Kastan MB and McKenna WG, editors. Clinical Oncology. 3rd ed. Philadelphia: Elsevier; 2004. p. 1073-1089.

Huang K, Hsu IC. Cervical Cancer. In: Hansen EK, Roach M, editors. Handbook of Radiation Oncology. New York: Springer, 2007. p. 335-346.

Huang K, Hsu IC. Endometrial cancer. In: Hansen EK, Roach M, editors. Handbook of Radiation Oncology. New York: Springer, 2007. p. 349-357.

Huang K, Quivey JM. Oropharyngeal cancer. In: Hansen EK, Roach M, editors. Handbook of Radiation Oncology. New York: Springer, 2007. p. 87-93.

Sneed PK, Kased N, Huang K, Rubenstein JL. Brain metastases and neoplastic meningitis. In: Abeloff MD, Armitage JO, Niederhuber JE, Kastan MB and McKenna WG, editors. Clinical Oncology. 4^th ed. Philadelphia: Elsevier; 2008, in press.