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Professional Focus

Dr. Patricia (Penny) K. Sneed is a radiation oncologist with a special interest in the treatment of breast and brain cancer. She also researches new treatments for these conditions, specifically using the gamma knife. Sneed is the recipient of numerous awards, including the Fellowship in the American College of Radiology. She earned her medical degree from Stanford University and completed a residency in radiation oncology at the University of California, San Francisco. She is a Professor in Residence in the department of Radiation Oncology at UCSF.

Education

Professional Experience

Awards & Honors

Publications - Partial Listing since 2000 (Out of 85)

Ojemann SG, Sneed PK, Larson DA, Gutin PH, Berger MS, Verhey L, et al. Radiosurgery for malignant meningioma: results in 22 patients. J Neurosurg 93(Suppl 3):62-67, 2000.

Goodman KA, Sneed PK, McDermott MW, Shiau C-Y, Lamborn KR, Chang S, et al. Relationship between pattern of enhancement and local control of brain metastases after radiosurgery. Int J Radiat Oncol Biol Phys 50(1):139-146, 2001.

Hoffman R, Sneed PK, McDermott MW, Chang S, Lamborn KR, Park E, et al. Radiosurgery for brain metastases from primary lung carcinoma. Cancer J Sci Amer 7(2):121-131, 2001.

Pirzkall A, McKnight T, Graves EE, Carol MP, Sneed PK, Wara WW, et al. MR-spectroscopy guided target delineation for high-grade gliomas. Int J Radiat Oncol Biol Phys 50(4):915-928, 2001.

Barker FG 2nd, Simmons ML, Chang SM, Prados MD, Larson DA, Sneed PK, et al. EGFR overexpression and radiation response in glioblastoma multiforme. Int J Radiat Oncol Biol Phys 51(2):410-418, 2001.

Sanghavi SN, Miranpuri SS, Chappell R, Buatti JM, Sneed PK, Suh JH, et al. Radiosurgery for patients with brain metastases: a multi-institutional analysis, stratified by the RTOG recursive partitioning analysis method. Int J Radiat Oncol Biol Phys 51(2):426-434, 2001.

Nakamura JL, Verhey LJ, Smith V, Petti PL, Lamborn KR, Larson DA, Wara WM, McDermott MW, Sneed PK. Dose conformity of Gamma Knife radiosurgery and risk factors for complications. Int J Radiat Oncol Biol Phys 51(5):1313-1319, 2001.

Barker FG 2nd, Chang SM, Larson DA, Sneed PK, Wara WM, Wilson CB, Prados MD. Age and radiation response in glioblastoma multiforme. Neurosurgery 49(6):1288-1298, 2001.

Sneed PK, Suh JH, Goetsch SJ, Sanghavi SN, Chappell R, Buatti JM, et al. A multi-institutional review of radiosurgery alone vs. radiosurgery with whole brain radiotherapy as the initial management of brain metastases. Int J Radiat Oncol Biol Phys 53(3):519-526, 2002.

Pirzkall A, Nelson SJ, McKnight TR, Takahashi MM, Li X, Graves EE, Verhey LJ, Wara WW, Larson DA, Sneed PK. Metabolic imaging of low-grade gliomas with three-dimensional magnetic resonance spectroscopy. Int J Radiat Oncol Biol Phys 53(5):1254-1264, 2002.

Nakamura JL, Pirzkall A, Carol MP, Xia P, Smith V, Wara WM, Petti PL, Verhey LJ, Sneed PK. Comparison of intensity-modulated radiosurgery with gamma knife radiosurgery for challenging skull base lesions. Int J Radiat Oncol Biol Phys 55(1):99-109, 2003.

Lee N, Millender LE, Larson DA, Wara WM, McDermott MW, Kaplan MJ, Sneed PK.  Gamma knife radiosurgery for recurrent salivary gland malignancies involving the base of skull. Head and Neck 25(3):210-216, 2003.

Ware ML, Larson DA, Sneed PK, Wara WM, McDermott MW. Surgical resection and permanent brachytherapy for recurrent atypical and malignant meningiomas. Neurosurgery 54(1):55-64, 2004.

Larson DA, Suplica JM, Chang SM, Lamborn KR, McDermott MW, Sneed PK, Prados MD, Wara WM, Nicholas MK, Berger MS. Permanent iodine 125 brachytherapy in patients with progressive or recurrent glioblastoma multiforme. Neuro-Oncology 6(2):119-126, 2004.

McDermott MW, Berger MS, Kunwar S, Parsa AT, Sneed PK, Larson DA. Stereotactic radiosurgery and interstitial brachytherapy for glial neoplasms. Journal of Neurooncology 69(1-3):83-100, 2004.

Chang SM, Lamborn KR, Malec M, Larson D, Wara W, Sneed P, Rabbit J, Page M, Nicholas MK, Prados MD. Phase II study of temozolomide and thalidomide with radiation therapy for newly diagnosed glioblastoma multiforme.  International Journal of Radiation Oncology, Biology, Physics 60(2):353-357, 2004.

Butowski N, Prados MD, Lamborn KR, Larson DA, Sneed P, Wara WM, Malec M, Rabbit J, Page M, Chang SM. A phase II study of concurrent temozolomide and cis-retinoic acid with radiation for adult patients with newly diagnosed supratentorial glioblastoma. International Journal of Radiation Oncology, Biology, Physics 61(5):1454-1459, 2005.

McDermott MW, Sneed PK. Radiosurgery in metastatic brain cancer.  Neurosurgery 57(5 Suppl):S45-S53, 2005.

Butowsksi NA, Sneed PK, Chang SM. Diagnosis and treatment of recurrent high-grade astrocytomas. Journal of Clinical Oncology 24(8):1273-1280, 2006

Tihan T, Barletta J, Parney I, Lamborn K, Sneed PK, Chang S. Prognostic value of detecting recurrent glioblastoma multiforme in surgical specimens from patients after radiotherapy: should pathology evaluation alter treatment decisions? Human Pathology 37(3):272-282, 2006.

Chang SM, Butowski NA, Sneed PK, Garner IV. Standard treatment and experimental targeted drug therapy for recurrent glioblastoma multiforme. Neurosurgical Focus 20(4):E4, 2006.

Smith JS, Parney IF, Lamborn KR, McDermott MW, Sneed PK, Chang SM. Treatment for posterior fossa dissemination of primary supratentorial glioma. Journal of Neurosurgery 106(4):567-74, 2007.

Chen AM, Chang S, Pouliot J, Sneed PK, Prados MD, Lamborn KR, Malec MK, McDermott MW, Berger MS, Larson DA. Phase I trial of gross total resection, permanent iodine-125 brachytherapy, and hyperfractionated radiotherapy for newly diagnosed glioblastoma multiforme. International Journal of Radiation Oncology, Biology, Physics 69(3):825-30, 2007.

Dagnew E, Kanski J, McDermott MW, Sneed PK, McPherson C, Breneman JC,Warnick RE. Management of newly diagnosed single brain metastasis using resection and permanent iodine-125 seeds without initial whole-brain radiotherapy: a two institution experience. Neurosurgical Focus 22(3):E3, 2007.

Kased N, Huang K, Nakamura JL, Sahgal A, Larson DA, McDermott MW, Sneed PK.  Gamma Knife radiosurgery for brainstem metastases: the UCSF experience. Journal of Neuro-Oncology 86(2):195-205, 2008.

Melisko ME, Moore DH, Sneed PK, DeFranco J, Rugo HS. Brain metastases in breast cancer:  clinical and pathological characteristics associated with improvements in survival. Journal of Neuro-Oncology (in press), 2008.

Huang K, Sneed PK, Kunwar S, Kragten A, Berger MS, Larson DA, Pouliot J, McDermott MW. Surgical resection and permanent iodine-125 brachytherapy for brain metastases. Journal of Neuro-Oncology (accepted pending minor revision)