Dr. Chuang is the primary physicist responsible for treatment planning, quality assurance and supervision of daily Cyberknife treatments. She also shares the responsibility of overseeing and planning for IMRT treatments, as well as planning and treatment for HDR Brachytherapy when needed.
Her main research interest involves the study of patient motion using on-line imaging, including intra- and inter-fractional patient motion for head and neck IMRT treatment, and more recently, respiratory motion and its effects on treatments of lung and liver cancers. She has also been involved heavily in investigation and implementation of various new technologies for clinical quality assurance, such as the use of MOSFET for routine IMRT QA measurements, Computed Radiography (CR) system for daily portal imaging, and calibration of amorphous silicon electronic portal imaging for exit beam dosimetry. She is currently investigating the CIRS Dynamic Motion Anthropomorphic Phantom for quality assurance testing of respiratory tracking/compensated radiation treatments. She is also in the process of facilitating a research collaboration with Calypso Medical Technologies, Inc., to study the feasibility of using its invention for respiratory gated radiotherapy on Siemens linear accelerators.
Awards & Honors
Recent Significant Publications
Descovich M, Ma L, Chuang CF, Larson DA, Barani IJ., Comparison between prone and supine patient setup for spine stereotactic body radiosurgery. Technol Cancer Res Treat. 2012 Jun;11(3):229-36.
Lupo JM, Chuang CF, Chang SM, Barani IJ, Jimenez B, Hess CP, Nelson SJ., 7-tesla susceptibility-weighted imaging to assess the effects of radiotherapy on normal-appearing brain in patients with glioma. Int J Radiat Oncol Biol Phys. 2012 Mar 1;82(3):e493-500.
Jabbari S, Weinberg VK, Kaprealian T, Hsu IC, Ma L, Chuang C, Descovich M, Shiao S, Shinohara K, Roach M 3rd, Gottschalk AR., Stereotactic body radiotherapy as monotherapy or post-external beam radiotherapy boost for prostate cancer: technique, early toxicity, and PSA response.
Shiao SL, Sahgal A, Hu W, Jabbari S, Chuang C, Descovich M, Hsu IC, Gottschalk AR, Roach M 3rd, Ma L., Temporal compartmental dosing effects for robotic prostate stereotactic body radiotherapy. Phys Med Biol. 2011 Dec 21;56(24):7767-75.
Kirby N, Chuang C, Pouliot J, Hwang A, Barani IJ., Physics strategies for sparing neural stem cells during whole-brain radiation treatments. Med Phys. 2011 Oct;38(10):5338-44.
Kirby N, Chuang C, Pouliot J., A two-dimensional deformable phantom for quantitatively verifying deformation algorithms. Med Phys. 2011 Aug;38(8):4583-6.
Dieterich S, Cavedon C, Chuang CF, Cohen AB, Garrett JA, Lee CL, Lowenstein JR, d'Souza MF, Taylor DD Jr, Wu X, Yu C., Report of AAPM TG 135: quality assurance for robotic radiosurgery. Med Phys. 2011 Jun;38(6):2914-36.
Ma L, Petti P, Wang B, Descovich M, Chuang C, Barani IJ, Kunwar S, Shrieve DC, Sahgal A, Larson DA., Apparatus dependence of normal brain tissue dose in stereotactic radiosurgery for multiple brain metastases.
Descovich M, Sneed PK, Barbaro NM, McDermott MW, Chuang CF, Barani IJ, Nakamura JL, Lijun M., A dosimetric comparison between Gamma Knife and CyberKnife treatment plans for trigeminal neuralgia. J Neurosurg. 2010 Dec;113 Suppl:199-206.
Ma L, Sahgal A, Descovich M, Cho YB, Chuang C, Huang K, Laperriere NJ, Shrieve DC, Larson DA., Equivalence in dose fall-off for isocentric and nonisocentric intracranial treatment modalities and its impact on dose fractionation schemes. Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3):943-8.
Hossain S, Xia P, Huang K, Descovich M, Chuang C, Gottschalk AR, Roach M 3rd, Ma L., Dose gradient near target-normal structure interface for nonisocentric CyberKnife and isocentric intensity-modulated body radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys. 2010 Sep 1;78(1):58-63.
Ma L, Sahgal A, Hossain S, Chuang C, Descovich M, Huang K, Gottschalk A, Larson DA., Nonrandom intrafraction target motions and general strategy for correction of spine stereotactic body radiotherapy. Int J Radiat Oncol Biol Phys. 2009 Nov 15;75(4):1261-5.
A. Sahgal, C. Ames, D. Chou, L. Ma, K. Huang, W. Xu, V. Weinberg, C. Chin, C. Chuang, P. Weinstein, D. Larson, Stereotactic Body Radiosurgery is Effective Salvage Therapy for Patients with Prior Radiation of Spinal Metastases, Int. J. of Rad. Oncol. Biol. Phys. accepted, 2008.
L. Ma, L. Verhey, M. McDermott, K. Huang, C. Chuang, V. Smith and P. Sneed, Effect of Composite Sector Collimation on Average Dose Fall-off for Gamma Knife Perfexion, J. Neurosurgery, in press, 2008.
L. Ma, A. Sahgal, C. Chuang, M. Descovich, P. Petti, V. Smith, L. Verhey, N. Barbaro, M. McDermott, K. Huang, J. Nakamura, P. Sneed, D. Larson, Functional Relationship Between the Volume of a Near-Target Peripheral Isodose Line and its Isodose Value for Gamma Knife Radiosurgery, Radiosurgery, in press 2008.
A. Sahgal, L. Ma, C. Chuang, S. Hossain, P. Petti, D. Larson, D. Shrieve, Comparisons of Novalis and Cyberknife Spinal Stereotactic Body Radiotherapy Treatment Planning Based on Physical and Biologic Modelling Parameters, Radiosurgery, in press 2008.
L. Ma, C. Chuang, M. Descovich, P. Petti, V. Smith and L. Verhey, Whole-procedure accuracy of Gamma Knife treatments of large lesions, Medical Phys. in press, 2008.
S. Hossain, P. Xia, C. Chuang, A. Gottschalk, G. Mu, L. Verhey and L. Ma, Simulated Real Time Image Guided Intra-Fraction Tracking Delivery for Hypofractionated Prostate IMRT, Medical Phys. 35 (9), 4041-4048, 2008.
K. Huang, P. Xia, C. Chuang, V. Weinberg, C. Glatsonbury, D. Eisele, N. Lee, S. Yom, T. Phillips, J. Quivery, Intensity-Modulated Chemoradiation for Treatment of Stage III and IV Oropharyngeal Carcinoma: The University of California-San Francisco Experience, Cancer. 113 (3), 497-507, 2008.
C. F. Chuang, D. A. Larson, A. Zytovicz, V. Smith, P. L. Petti, Peripheral Dose Measurement for CyberKnife Radiosurgery with Upgraded Linac Shielding, Medical Phys. 35 (4), 1494-1496, 2008.
A. Sahgal, C. Chuang, D. Larson, K. Huang, P. Petti, P. Weinstein, L. Ma, Split-Volume Treatment Planning of Multiple Consecutive Vertebral Body Metastases for Cyberknife Image-Guided Robotic Radiosurgery, Medical Dosimetry. 33 (3), 175-179, 2008.
A. Sahgal, D. Chou, C. Ames, L. Ma, K. Lamborn, K. Huang, C. F. Chuang, A. Aiken, P. Petti, P. Weinstein, D. Larson, Image-Guided Robotic Stereotactic Body Radiotherapy for Benign Spinal Tumors: the University of California San Francisco Preliminary Experience, Technology in Cancer Research & Treatment. 6 (6), 595-604, 2007.
L. Ma, D. Larson, P. Petti, C. Chuang, L. Verhey, Boosting Central Target Dose by Optimizing Embedded Dose Hot Spots for Gamma Knife Radiosurgery, Stereotact Funct Neurosurg. 85 (6), 259-263, 2007.
C. F. Chuang, A. Sahgal, L. Lee, D. Larson, K. Huang, P. Petti, L. Verhey, L. Ma, Effects of Residual Target Motion Errors for Imaging Tracked Robotic Hypofractionated Radiotherapy Delivery, Med. Phys. 34 (11), 4484-4490, 2007.
C. F. Chuang, A. Chan, D. Larson, L. Verhey, M. McDermott, S. Nelson, A. Pirzkall, Potential Value of MR Spectroscopic Imaging for the Radiosurgical Management of Patients with Recurrent High-Grade Gliomas, Technology in Cancer Research & Treatment. 6 (5), 375-382, 2007.
A. Zytkovicz, I. Daftari, T. L. Phillips, C. F. Chuang, L. Verhey, P. L. Petti, Peripheral Dose in Ocular Treatment with CyberknKinife and Gamma Knife radiosurgery compared to Proton Radiotherapy, Phys. Med. Biol. 52 (19), 5957-5971, 2007.
I. Park, G. Tamai, M. C. Lee, C. F. Chuang, S. M. Chang, M.S. Berger, S.J. Nelson, A. Pirzkall, Patterns of Recurrence Analysis in Newly Diagnosed Glioblastoma Multiforme after Three-Dimensional Conformal Radiation Therapy with respect to Pre-Radiation Therapy Magnetic Resonance Spectroscopic Findings, Int. J. Radiat. Oncol. Biol. Phys. 69(2), 381-389, 2007.