Josephine Chen

Josephine Chen, Ph.D.

Assistant Professor
Division of Physics
Department of Radiation Oncology

University of California, San Francisco
Helen Diller Family Comprehensive Cancer Center
Box 1708, 1600 Divisadero St, H1031
San Francisco, CA 94115
Phone: (415) 353-7175
Fax: (415) 885-7349
Email: Josephine.Chen[at]

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Professional Focus

Dr. Chen’s primary clinical responsibility is the support of the external beam treatment planning systems and process. She coordinates the quality assurance program for the CT simulators. She also oversees the commissioning, maintenance, and quality assurance of external beam treatment planning computer systems. She provides clinical support for the linac-based SBRT program as well as the development and evaluation of radiation plans for complex cases, such as patients undergoing retreatment. She also works closely with the therapy and dosimetry staff to develop standard procedures, provides training, and resolves issues.

One of Dr. Chen’s major research efforts is the study of dosimetric predictors of normal tissue toxicity in collaboration with clinical experts in Radiation Oncology as well as other departments. She is part of the head-and-neck research group which has several ongoing projects. She is also part of a cooperative effort to establish a robust research platform, combining radiation data with other key clinical data. A second major research interest is the clinical utilization of advanced imaging techniques, such as deformable image registration (DIR). She is part of a research group investigating clinical applications of DIR. There are several ongoing projects evaluating the accuracy of DIR algorithms, developing methods of estimating the uncertainty of DIR, and exploring the application of DIR for adaptive radiation therapy techniques.



Harvard University, Cambridge, MA

AB Magna Cum Laude, Physics

University of California, Berkeley, CA

PhD Physics

University of California, San Francisco, CA

Medical Physics Post-Doctoral Radiation Oncology
2006-2007 University of California, San Francisco, CA Medical Physics Resident Radiation Oncology


Professional Experience

2010-present UCSF Assistant Professor Radiation Oncology
2008-2010 UCSF Clinical Instructor Radiation Oncology


Recent Significant Publications :

Braunstein S, Glastonbury CM, Chen J, Quivey JM, Yom SS. The Impact of Radiology-Based Peer Review on Head and Neck Radiotherapy Target Delineation. Am J Neuroradiology 2015 (accepted)

Descovich M, McGuinness C, Kannarunimit D, Chen J, Pinnaduwage D, Pouliot J, Kased N, Gottschalk A, Yom SS. Comparison Between Target Margins Derived from 4DCT Scans and Real-Time Tumor Motion Tracking: Insights from Lung Tumor Patients Treated with Robotic Radiosurgery. Med Phys 2015; 42:1280-7.

Kannarunimit D, Descovich M, Garcia A, Chen J, Weinberg V, McGuinness C, Pinnaduwage D, Murnane J, Gottschalk AR, Yom SS. Analysis of Dose Distribution and Risk of Pneumonitis in Stereotactic Body Radiation Therapy for Centrally Located Lung Tumors: A Comparison of Robotic Radiosurgery, Helical Tomotherapy and Volumetric Modulated Arc Therapy. Technol Cancer Res Treat 2015; 14:49-60.

Chyan A, Chen J, Shugard E, Lambert L, Quivey JM, Yom SS. Dosimetric Predictors of Hypothyroidism in Oropharyngeal Cancer Patients Treated with Intensity-Modulated Radiation Therapy. Radiat Oncol 2014; 9(1):269.

Graff P, Kirby N, Weinberg V, Chen J, Yom SS, Lambert L, Pouliot J. The residual setup errors of different IGRT alignment procedures for head and neck IMRT and the resulting dosimetric impact. Int J Radiat Oncol Biol Phys 2013; 86(1):170-6.

Hwang AB, Chen J, Nguyen TB, Gottschalk AG, Roach MR, Pouliot J. Irradiation of the prostate and pelvic lymph nodes with an adaptive algorithm. Med Phys 2012; 39(2):1119-24.

Chen J, Irion J, Faddegon BA. Validation of the final aperture superposition technique to calculate electron output factors and depth dose curves. Med Phys 2009; 36(8):3397-405.