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Clinical Trials

From the central nervous system (CNS) or Brain, to the Head and Neck, to the Prostate, some of the most important clinical trials completed to date have been lead by investigators from UCSF. Numerous studies on CNS tumors have addressed issues related to defining optimal drugs, radiation type (brachytherapy or radioactive seeds, gamma-knife), and the use of hyperthermia (heat). The largest randomized trial ever completed involving Head and Neck Cancer studying optimal fractionation schemes was designed and chaired by Karen Fu, ASTRO Gold Medalist winner, from UCSF. The largest Prostate Cancer trial completed to date, evaluating the impact of radiation field on outcomes, was designed and chaired by an investigator from UCSF. As a leading research institution UCSF fields numerous clinical trials in many areas at one time. More information on clinical trials and current open studies follows:

Current Trials

Principal Investigator Study Title Disease Status
Albert Chan RTOG-0926
A Phase ll Protocol for Patients with Stage T1 Bladder Cancer to Evaluate Selective Bladder Preserving Treatment by Radiation Therapy Concurrent with Radiosensitizing Chemotherapy Following a Thorough Transurethral Surgical Re-Staging.
Bladder Cancer Open
Igor Barani,

Dave Larson
NAGKC-12-01
A Randomized Controlled Study of Neurocognitive Outcomes in Patients with Five or More Brain Metastases Treated with Radiosurgery or Whole-Brain Radiotherapy.
Brain Cancer Open
Sue Yom,

Jeanne Quivey
RTOG 0920
A Phase III Study of Postoperative Radiation Therapy (IMRT)
+/- Cetuximab for Locally-Advanced Resected Head and Neck Cancer.
Head & Neck Cancer Open
Sue Yom,

Jeanne Quivey
RTOG 1016
A Phase III Trial of Radiotherapy Plus Cetuximab Versus Chemoradiotherapy in HPV-Associated Oropharynx Cancer.
Head & Neck Cancer Open
Sue Yom,

Jeanne Quivey
RTOG 1008
A Randomized Phase I I Study of Adjuvant Concur rent Radiation and Chemotherapy versus Radiation Alone in Resected High-Risk Malignant Salivary Gland Tumors.
Head & Neck Cancer Open
Jeanne Quivey, Sue Yom

RTOG 0912
A Phase I I Study of Concur rent IMRT, Paclitaxel and Pazopanib (NSC 737754) or Placebo, for the treatment of Anaplastic T hyroid Cancer.
Head & Neck Cancer Open
Sue Yom
VISMO-122011
A Phase ll study of Radiation Therapy and Vismodegib, for the Treatment of Locally Advanced Basal Cell Carcinoma of the Head and Neck.
Head & Neck Cancer Open
Sue Yom
RTOG 1216
Randomized Phase ll/lll Trial of Surgery and Postoperative Radiation Delivered with Concurrent Cisplatin Versus Docetaxel Versus Docetaxel and Cetuximab for High-Risk for Squamous Cell Cancer of the Head and Neck.
Head & Neck Cancer Open
Sue Yom
RTOG 1306
A Randomized Phase ll Study of Individualized Combined Modality Therapy for Stage lll Non-Small Cell Lung Cancer (NSCLC).
Lung Cancer Open
Mack Roach N/A
Pre-Operative Gleason Score and PSA and Clinical Stage in Predicting the Risk of Failure in Patients Undergoing Radiation Therapy for Localized Prostate Cancer.
Prostate Cancer Open
Mack Roach,

Alexander Gottschalk, Albert Chang, I-Chow Joe Hsu
RTOG 1115
Phase III Trial of Dose Escalated Radiation Therapy and Standard Androgen Deprivation Therapy (ADT) with a GnRH Agonist vs. Dose Escalated Radiation Therapy and Enhanced ADT with a GnRH Agonist and TAK-700 for Men with High Risk Prostate Cancer.
Prostate Cancer Open
Mack Roach,

Alexander Gottschalk,
I-Chow Joe Hsu
RTOG 0924
Androgen Deprivation Therapy and High Dose Radiotherapy With or Without Whole-Pelvic Radiotherapy in Unfavorable Intermediate or Favorable High Risk Prostate Cancer: A Phase III Randomized Trial.
Prostate Cancer Open
Igor Barani 13991
A Phase III Randomized Study Comparing Two Dosing Schedules for Hypofractionated ImageGuided Radiation Therapy in Patients with Metastatic Cancer.
Spine Cancer Open

For more information about clinical trials http://www.clinicaltrials.gov/ct/info/whatis#whatis