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From the central nervous system (CNS) or Brain, to the Head and Neck, to the Prostate, some of the most important clinical trials completed to date have been lead by investigators from UCSF. Numerous studies on CNS tumors have addressed issues related to defining optimal drugs, radiation type (brachytherapy or radioactive seeds, gamma-knife), and the use of hyperthermia (heat). The largest randomized trial ever completed involving Head and Neck Cancer studying optimal fractionation schemes was designed and chaired by Karen Fu, ASTRO Gold Medalist winner, from UCSF. The largest Prostate Cancer trial completed to date, evaluating the impact of radiation field on outcomes, was designed and chaired by an investigator from UCSF. As a leading research institution UCSF fields numerous clinical trials in many areas at one time. More information on clinical trials and current open studies follows:
Current Trials
| Principal Investigator |
Study Title |
Disease |
Status |
Igor Barani,
Penny Sneed,
Daphne Haas-Kogan, and Jean Nakamura |
RTOG 0539
A Phase II Trial of Observation for Low-Risk Meningiomas and of Radiotherapy for Intermediate- and High-Risk Meningiomas. |
Brain Cancer |
Open |
Alexander Gottschalk,
Igor Barani,Shannon Fogh,
Penny Sneed,
Sue Yom |
RTOG 0631
Image-Guided Radiosurgery or Stereotactic Body Radiation Therapy in Treating Patients With Localized Spine Metastasis. |
CNS Cancer |
Open |
| Barbara Fowble |
ECOG2108/RTOG 1173
A Randomized Phase III Trial of the Value of Early Local Therapy for the Intact Primary Tumor in Patients with Metastatic Breast Cancer. |
Breast Cancer |
Open |
Sue Yom,
Jeanne Quivey |
RTOG 0920
A Phase III Study of Postoperative Radiation Therapy (IMRT)
+/- Cetuximab for Locally-Advanced Resected Head and Neck Cancer |
Head & Neck Cancer |
Open |
Sue Yom
Jeanne Quivey |
RTOG 1016
A Phase III Trial of Radiotherapy Plus Cetuximab Versus Chemoradiotherapy in HPV-Associated Oropharynx Cancer |
Head & Neck Cancer |
Open |
Sue Yom,
Jeanne Quivey |
RTOG 1008
A Randomized Phase I I Study of Adjuvant Concur rent Radiation
and Chemotherapy versus Radiation Alone in Resected High-Risk Malignant Salivary Gland
Tumors |
Head & Neck Cancer |
Open |
Jeanne Quivey, Sue Yom
|
RTOG 0912
A Phase I I Study of Concur rent IMRT, Paclitaxel and Pazopanib (NSC 737754) or Placebo, for the treatment of Anaplastic T hyroid Cancer |
Head & Neck Cancer |
Open |
Alexander Gottschalk,
Sue Yom,
Richard Krieg |
RTOG 0813
Seamless Phase I/II Study of Stereotactic Lung Radiotherapy (SBRT) for Early Stage, Centrally Located Non-Small Cell Lung Cancer (NSCLC) in Medically Inoperable Patients. |
Lung Cancer |
Open |
Alexander Gottschalk
Sue Yom
|
RTOG 0839
Randomized Phase II Study of Pre-operative Chemoradiotherapy +/- Panitumumab Followed by Consolidation Chemotherapy in Potentially Operable Locally Advanced (Stage IIIA, N2+) Non-Small Cell Lung Cancer |
Lung Cancer |
Open |
Sue Yom,
Alexander Gottschalk |
ACOSOG Z4099/RTOG 1021
A Randomized Phase III Study of Sublobar Resection (+/- Brachytherapy) versus Stereotactic Body Radiation Therapy in High Risk Patients with Stage I Non-Small Cell Lung Cancer (NSCLC). |
Lung Cancer |
Open |
Mack Roach,
Alexander Gottschalk,
I-Chow Joe Hsu |
RTOG 0831
A Randomized, Double-Blinded, Placebo-Controlled Phase III Trial to Evaluate the Effectiveness of a Phosphodiesterase 5 Inhibitor, Tadalafil, in Prevention of Erectile Dysfunction in Patients Treated with Radiotherapy for Prostate Cancer---RTOG CCOP Study |
Prostate Cancer |
Open |
| Mack Roach |
N/A
Pre-Operative Gleason Score and PSA and Clinical Stage in Predicting the Risk of Failure in Patients Undergoing Radiation Therapy for Localized Prostate Cancer. |
Prostate Cancer |
Open |
Mack Roach,
I-Chow Joe Hsu, Alexander Gottschalk |
RTOG 0526
Prospective Phase II Trial of Transperineal Ultrasound-Guided Brachytherapy for Locally Recurrent Prostate Adenocarcinoma Following External Beam Radiotherapy. |
Prostate Cancer |
Open |
Mack Roach
Alexander Gottschalk,
I-Chow Joe Hsu |
RTOG 0534
A Phase III Trial of Short Term Androgen Deprivation with Pelvic Lymph Node or Prostate Bed Only Radiotherapy (SPPORT) in Prostate Cancer Patients with a Rising PSA After Radical Prostatectomy. |
Prostate Cancer |
Open |
Mack Roach,
Alexander Gottschalk,
I-Chow Joe Hsu |
RTOG 0924
Androgen Deprivation Therapy and High Dose Radiotherapy With or Without Whole-Pelvic Radiotherapy in Unfavorable Intermediate or Favorable High Risk Prostate Cancer: A Phase III Randomized Trial. |
Prostate Cancer |
Open |
For more information about clinical trials http://www.clinicaltrials.gov/ct/info/whatis#whatis
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