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Clinical Trials

From the central nervous system (CNS) or Brain, to the Head and Neck, to the Prostate, some of the most important clinical trials completed to date have been lead by investigators from UCSF. Numerous studies on CNS tumors have addressed issues related to defining optimal drugs, radiation type (brachytherapy or radioactive seeds, gamma-knife), and the use of hyperthermia (heat). The largest randomized trial ever completed involving Head and Neck Cancer studying optimal fractionation schemes was designed and chaired by Karen Fu, ASTRO Gold Medalist winner, from UCSF. The largest Prostate Cancer trial completed to date, evaluating the impact of radiation field on outcomes, was designed and chaired by an investigator from UCSF. As a leading research institution UCSF fields numerous clinical trials in many areas at one time. More information on clinical trials and current open studies follows:

Current Trials

Principal Investigator Study Title Disease Status
Sue Yom,

Jeanne Quivey
RTOG 0920
A Phase III Study of Postoperative Radiation Therapy (IMRT)
+/- Cetuximab for Locally-Advanced Resected Head and Neck Cancer
Head & Neck Cancer Open

Sue Yom

Jeanne Quivey

RTOG 1016
A Phase III Trial of Radiotherapy Plus Cetuximab Versus Chemoradiotherapy in HPV-Associated Oropharynx Cancer

Head & Neck Cancer Open
Sue Yom,

Jeanne Quivey
RTOG 1008
A Randomized Phase I I Study of Adjuvant Concur rent Radiation
and Chemotherapy versus Radiation Alone in Resected High-Risk Malignant Salivary Gland
Tumors
Head & Neck Cancer Open
Jeanne Quivey, Sue Yom

RTOG 0912
A Phase I I Study of Concur rent IMRT, Paclitaxel and Pazopanib (NSC 737754) or Placebo, for the treatment of Anaplastic T hyroid Cancer
Head & Neck Cancer Open
Alexander Gottschalk,

Sue Yom,
RTOG 0813
Seamless Phase I/II Study of Stereotactic Lung Radiotherapy (SBRT) for Early Stage, Centrally Located Non-Small Cell Lung Cancer (NSCLC) in Medically Inoperable Patients.
Lung Cancer Open
Sue Yom,

Alexander Gottschalk
ACOSOG Z4099/RTOG 1021
A Randomized Phase III Study of Sublobar Resection (+/- Brachytherapy) versus Stereotactic Body Radiation Therapy in High Risk Patients with Stage I Non-Small Cell Lung Cancer (NSCLC).
Lung Cancer Open
Mack Roach N/A
Pre-Operative Gleason Score and PSA and Clinical Stage in Predicting the Risk of Failure in Patients Undergoing Radiation Therapy for Localized Prostate Cancer.
Prostate Cancer Open
Mack Roach,

I-Chow Joe Hsu, Alexander Gottschalk
RTOG 0526
Prospective Phase II Trial of Transperineal Ultrasound-Guided Brachytherapy for Locally Recurrent Prostate Adenocarcinoma Following External Beam Radiotherapy.
Prostate Cancer Open

Mack Roach,

Alexander Gottschalk,
I-Chow Joe Hsu

RTOG 0924
Androgen Deprivation Therapy and High Dose Radiotherapy With or Without Whole-Pelvic Radiotherapy in Unfavorable Intermediate or Favorable High Risk Prostate Cancer: A Phase III Randomized Trial.
Prostate Cancer Open

Mack Roach,

Alexander Gottschalk, Albert Chang,
I-Chow Joe Hsu

RTOG 0938
A Randomized phase II trial of Hypofractionated Radiotherapy for Favorable Risk Porstate Cancer.
Prostate Cancer Open

Mack Roach,

Alexander Gottschalk, Albert Chang,
I-Chow Joe Hsu

RTOG 1115
Phase III Trial of Dose Escalated Radiation Therapy and Standard Androgen Deprivation Therapy (ADT) with a GnRH Agonist vs. Dose Escalated Radiation Therapy and Enhanced ADT with a GnRH Agonist and TAK-700 for Men with High Risk Prostate Cancer.
Prostate Cancer Open

For more information about clinical trials http://www.clinicaltrials.gov/ct/info/whatis#whatis