Serah Choi, MD, PhD

Serah Choi

Educational Background

Radiation Oncology Residency, University of California San Francisco (2014-2018)

UPMC Medical Education Transitional Year Program, Pittsburgh, PA (2013-2014)

M.D., University of Pittsburgh (2013)

Ph.D., Molecular Pharmacology, University of Pittsburgh (2011)

B.A., Human Biological, Stanford University (1999)


Awards & Honors

NIH T32 GM08424 Pharmacology and Chemical Biology Training Program Grant (2009)

University of Pittsburgh Cancer Institute Molecular and Cellular Oncology Travel Award (2009)

John S. Lazo Cancer Pharmacology Fellowship (2008)

NIH T32 GM08208 Medical Scientist Training Program Grant (2005)

Stanford University Group Public Service Award (1999)

Stanford Undergraduate Research Opporttunities Grant (1998)

Selected Publications and Abstracts

O'Shea CC, Johnson L, Bagus B, Choi S, Nicholas C, Shen A, Boyle L, Pandey K, Soria C, Kunich J, Shen Y, Habets G, Ginzinger D, McCormick F. Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity. Cancer Cell. 2004. 6: 611-23. PMID: 15607965.

O'Shea C, Klupsch K, Choi S, Bagus B, Soria C, Shen J, McCormick F, Stokoe D. Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication. EMBO Journal. 2005. 24:1211-21. PMID: 15775987.

O'Shea CC, Choi S, McCormick F, Stokoe D. Adenovirus overrides cellular checkpoints for protein translation. Cell Cycle. 2005. 4:883-8. PMID: 1597069.

White JS, Choi S, Bakkenist CJ. Irreversible chromosome damage accumulates rapidly in the absence of ATM kinase activity. Cell Cycle. 2008. 7:1277-84. PMID: 18418045.

Goff JP, Shields DP, Seki M, Choi S, Epperly MW, Dixon T, Wang H, Bakkenist CJ, Dertinger S, Torous DK, Wittschieben J, Wood RD and Greenberger JS. Lack of DNA polymerase theta (POLQ) radiosensitizes bone marrow stromal cells in vitro and increases reticulocyte micronuclei after total-body irradiation. Radiation Research. 2009. 172:165-74. PMID: 19630521.

Momčilović O, Choi S, Varum S, Bakkenist CJ, Schatten G and Navara C. Ionizing radiation induces ATM-dependent checkpoint signaling and G2 cell cycle arrest in pluripotent human embryonic stem cells. Stem Cells. 2009. 27:1822-35. PMID: 19544417.

Rajagopalan MS, Stone B, Rwigema JC, Salimi U, Epperly MW, Goff J, Franicola D, Dixon T, Cao S, Zhang X, Buchholz BM, Bauer AJ, Choi S, Bakkenist C, Wang H, Greenberger JS. Intraesophageal manganese superoxide dismutase-plasmid liposomes ameliorates novel total-body and thoracic radiation sensitivity of NOS1-/- mice. Radiat Res. 2010. 4:297-312. PMID: 2072672

White JS, Choi S, Bakkenist CJ. 2010. Transient ATM Kinase Inhibition Disrupts DNA Damage–Induced Sister Chromatid Exchange.Science Signaling. 2010.3:ra44. PMID: 20516478.

Choi S, Gamper AM, White JS, Bakkenist CJ. Inhibition of ATM kinase activity does not phenocopy ATM protein disruption: implications for the clinical utility of ATM kinase inhibitors. Cell Cycle. 2010. 9:4052-7. PMID: 20953138.

Bista RK, Uttam S, Wang P, Staton K, Choi S, Bakkenist CJ, Hartman DJ, Brand RE, Liu Y. Quantification of nanoscale nuclear refractive index changes during the cell cycle. J Biomed Opt. 2011. 16:070503. PMID: 21806245

Choi S, Toledo LI, Fernandez-Capetillo O, Bakkenist CJ. CGK733 does not inhibit ATM or ATR kinase activity in H460 human lung cancer cells. DNA Repair (Amst). 2011. 10:1000-1. PMID: 2186509.

Gamper AM, Choi S, Matsumoto Y, Banerjee D, Tomkinson AE, Bakkenist CJ. ATM protein physically and functionally interacts with proliferating cell nuclear antigen to regulate DNA synthesis. J Biol Chem. 2012. 287:12445-54. PMID: 2236277.

Choi S, Srivas R, Fu K, Hood BL, Dost B, Houten BV, Bandeira N, Conrads TP, Ideker T, Bakkenist CJ. Quantitative proteomics reveals ATM kinase-dependent exchange in DNA damage response complexes.J Proteome Res. 2012. 11:4983-91. PMID: 22909323.

Qian W, Choi S, Gibson GA, Watkins SC, Bakkenist CJ, Houten BV. Mitochondrial hyperfusion induced by loss of fission protein Drp1 causes ATM-dependent G2/M arrest and aneuploidy through DNA replication stress. J Cell Sci. 2012. 125:5745-57. PMID: 23015593.

Uttam S, Bista RK, Staton K, Alexandrov S, Choi S, Bakkenist CJ, Hartman DJ, Brand RE, Liu Y. Investigation of depth-resolved nanoscale structural changes in regulated cell proliferation and chromatin decondensation. Biomed Opt Express. 2013. 4:596-613. PMID: 23577294.

Choi S, Bakkenist CJ. Brd4 shields chromatin from ATM kinase signaling storms. Sci Signal. 2013. 6:pe30. PMID: 24045152.