Our Team
John P. Murnane, Ph.D.
Professor
Department of Radiation Oncology
Meet Dr. Murnane
Education
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Professional Experience
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Recent Significant PublicationsMurnane, J. P. Telomere loss as a mechanism for chromosome instability in human cancer. Cancer Res., 70:4255-4259 (2010). Reynolds, G.E., Gao, Q., Miller, D., Snow, B.E., Harrington, L.A., and Murnane J.P. The role of PIF1 and NBS1 in chromosome healing and fusion resulting from double-strand breaks near telomeres in murine embryonic stem cells. DNA Repair, 10:1164-1173 (2011). Miller, D., Reynolds, G.E., Mejia, R., Stark, J.M., and Murnane, J.P. Subtelomeric regions in mammalian cells are deficient in DNA double-strand break repair. DNA Repair10:536-544 (2011). Murnane, J.P. Telomeric dysfunction and chromosome instability. Mutat. Res. 730:28-36 (2012). Muraki, K., Nyhan, K., Han, L., and Murnane, J.P. Mechanisms of telomere loss and their consequences for chromosome instability. Front. Oncol. 2:135 (2012). Muraki, K., Han, L., Miller, D., and Murnane, J.P. The role of ATM in the deficiency in nonhomologous end-joining near telomeres in a human cancer cell line. PLoS Genetics, 9:e1003386 (2013). Li, Z., Hudson, F.Z., Wang, H., Wang, Y., Bian, Z., Murnane, J.P., and Dynan, W.S. Increased mutagenic joining of enzymatically-induced DNA double-strand breaks in high-charge and energy particle irradiated human cells. Radiation Res. 180:17 (3013). Li, Z., Wang, H., Wang, Y., Murnane, J.P., and Dynan, W.S. Effect of radiation quality on mutagenic joining of enzymatically-induced DNA double-strand breaks in previously irradiated human cells. Radiation Res. In press (2014). Bakhoum, S.F., Kabeche, L., Murnane, J.P., Zaki, B.I., and Compton, D.A. DNA-damage response during mitosis induces whole-chromosome missegregation. Cancer Discov. 4:1281-9 (2014). Bakhoum, S.F., Kabeche, L., Wood, M.D., Laucius, D., Qu, D., Laughney, A.M., Reynolds, G.E., Louie, R.J., Phillips, J., Chan, D.A., Bassem, I.Z., Murnane, J.P., Petritsch, C., and Compton, D.A. Numerical chromosomal instability mediates susceptibility to radiation treatment. Nature Commun. 6:5990 (2015). Muraki, K., Han, L, Miller, D., and Murnane, J. P. Processing by MRE11 is involved in the sensitivity of subtelomeric regions to DNA double-strand breaks. Nucleic Acids Res. doi: 10.1093/nar/gkv714 (2015). |