We at UCSF take your care seriously. Click here for COVID-19 information

University of California San Francisco

Our Team

Jie Jane Chen

Krystal Straessler, MD, PhD



  • Radiation Oncology Medical Residency Training Program, University of California, San Francisco (2023 – 2027)
  • Transitional Year Internship, Abrazo Health Network (2022-2023)
  • M.D., University of Utah School of Medicine (2017-2022)
  • Postdoctoral Fellow, University of California San Francisco (2017-2020)
  • Postdoctoral Fellow, Stanford University (2015-2017)
  • Ph.D., Human Genetics, University of Utah (2008-2014)
  • M.S., Clinical Investigation, University of Utah (2014)
  • B.S., Molecular Biosciences and Biotechnology, Arizona State University (2004-2007)

Awards & Honors

  • Gold Humanism Honor Society (2021)
  • Sarcoma Summer Medical Student Research Award (2018)
  • First Place Poster Award, Stanford Cancer Systems Biology Symposium (2017)
  • Cancer Systems Biology Scholar, National Cancer Institute (2015-2017)
  • NIH Principal Investigator (NIH, SBIR Phase I) (2015)
  • Genetics Training Scholar (NIH, T32) (2013-2014)
  • Med-to-Grad Scholar, Howard Hughes Medical Institute (2011-2013)
  • National Science and Mathematics Access to Retain Talent (SMART) Award (2006-2007)
  • Magna Cum Laude, Arizona State University (2007)
  • Deans List, Arizona State University (2005-2007)

Selected Publications, Abstracts, and Posters

  • Hutten RJ, Fenlon JB, Kessel AC, Straessler KM, Huang YJ, Gaffney DK, Suneja G, Zempolich K, Burt LM. Radical trachelectomy and adjuvant vaginal brachytherapy to preserve fertility in pediatric cervical adenocarcinoma. Brachytherapy. 2022 Nov-Dec;21(6):764-768. doi: 10.1016/j.brachy.2022.06.004. Epub 2022 Aug 13. PMID: 35973904.
  • Avanthi Tayi Shah, Tej D. Azad, Marcus R Breese, Jacob J. Chabon, Emily Hamilton, Krystal Straessler, David M. Kurtz, Stanley G Leung, Aviv Spillinger, Heng-Yi Liu, Inge H Behroozfard, Frederick M. Wittber, Florette K Hazard, Soo-Jin Cho, Heike E Daldrup-Link, Kieuhoa T Vo, Arun Rangaswami, Allison Pribnow, Sheri L. Spunt, Norman J Lacayo, Maximilian Diehn, Ash A. Alizadeh, and E. Alejandro Sweet-Cordero. A comprehensive circulating tumor DNA assay for detection of translocation and copy number changes in pediatric sarcomas. Mol Cancer Ther. 2021 Oct;20(10):2016-2025. doi: 10.1158/1535-7163.MCT-20-0987. Epub 2021 Aug 5. PMID: 34353895; PMCID: PMC9307079.
  • Panza E, Ozenberger BB, Straessler KM, Barrott JJ, Li L, Wang Y, Xie M, Boulet A, Titen SWA, Mason CC, Lazar AJ, Ding L, Capecchi MR, Jones KB. The clear cell sarcoma functional genomic landscape. J Clin Invest. 2021 Jun 22:146301. doi: 10.1172/JCI146301. Epub ahead of print. PMID: 34156976.
  • Sayles LC, Breese MR, Koehne AL, Leung SG, Lee AG, Liu HY, Spillinger A, Shah AT, Tanasa B, Straessler K, Hazard FK, Spunt SL, Marina N, Kim GE, Cho SJ, Avedian RS, Mohler DG, Kim MO, DuBois SG, Hawkins DS, Sweet-Cordero EA. Genome-Informed Targeted Therapy for Osteosarcoma. Cancer Discov. 2019;8:46-63.  
  • Goodwin M, Huifeng J, Straessler KM, Smith-Fry K, Zhu JF, Monument M, Grossmann A, Randall RL, Capecchi MR, Jones KB. Modeling alveolar soft part sarcomagenesis in the mouse: a role for lactate in tumor microenvironment. Cancer Cell.2014;26:851-862. 
  • Straessler KM, Jones KB, Hu H, Jin H, van de Rijn M, Capecchi MR. Modeling clear cell sarcomagenesis in the mouse: Cell of origin differentiation state impacts tumor characteristics. Cancer Cell. 2013;23:215-227
  • Spetzler D, York J, Dobbin C, Martin J, Ishmukhametov R, Day L, Yu J, Kang H, Porter K, Hornung T, Frasch WD. Recent developments of bio-molecular motors as on-chip devices using single molecule techniques. Lab Chip. 2007;7:1633-1643
  • Straessler, K., Ruping, S., Leung, S., Spillinger, A., Zhicheng, M., Hazard, F.K., Sweet-Cordero, A. and C. Curtis. Delineating the evolutionary dynamics of osteosarcoma progression through spatio-temporal genomic profiling. Cancer Systems Biology Symposium. Stanford, CA (2017)
  • Straessler, K., Ruping, S., Leung, S., Hazard, F.K., Sweet-Cordero, A. and C. Curtis. Understanding the Genomic Evolution of Osteosarcoma Using Longitudional Multisampling. Cancer Biology Retreat, Stanford CA (2016)
  • Straessler, K., Jones, K.B., and M.R. Capecchi. EWS-ATF1 Fusion Oncogene, Sufficient and Necessary in Initiation of Clear Cell Sarcomagenesis.  NIH Genetics Training Grant Annual Meeting, Park City, UT (2014)
  • Straessler, K., Jones, K.B., and M.R. Capecchi. Clear Cell Sarcoma, A study of cell of origin and how it shapes the tumor phenotype. Human Genetics Program Annual Retreat, Park City, UT (2013)
  • Straessler, K, Pozner, A., and M.R. Capecchi. “Role of Bmi1 in Neural Stem Cells and Adult Neurogenesis” Keystone Symposia- Life of Stem Cells from Birth to Death Title Keystone Symposia- Life of Stem Cells from Birth to Death Title. (2012)
  • Straessler, K., Jones, K.B., and M.R. Capecchi. Modeling Clear Cell Sarcomagenesis. Molecular Medicine Annual Retreat, Park City, UT (2010)

Redefining Possible