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Alexander R. Gottschalk, MD, PhD

Professor and Vice-Chair
Department of Radiation Oncology

Meet Dr. Gottschalk

I am motivated to improve the lives of patients and families today and impact many more in the future

Dr. Gottschalk is involved in a number of clinical research projects. First, he has studied several methods of image-guided radiotherapy (IGRT), including ultrasound, electronic portal imagining using gold seed fiducial markers and megavoltage cone-beam CT (MVCBCT). His research is one of the first to evaluate prostate bed motion in patients undergoing radiotherapy after prostatectomy. Dr. Gottschalk has investigated the use of MVCBCT for dose calculation and re-calculation as well as a novel high quality, low dose, imaging beam line. The dose re-calculation can be used for dose guided radiation therapy (DGRT). Second, using the Radiation Oncology clinical database, Dr. Gottschalk has studied: the effectiveness of intraoperative radiation therapy (IORT) in the management of extremity sarcomas and renal cell carcinoma recurrences, permanent seed brachytherapy and high dose-rate brachytherapy (HDR) for the treatment of prostate cancer both as primary therapy and as salvage after radiation failures. Third, he has been involved as a co-investigator in three trials: a phase II, single-center, open-label phase I/II study to evaluate efficacy and safety in patients who have resectable esophageal cancer and are treated with neoadjuvant cisplatin, irinotecan (CPT-11), ZD1839 (IRESSA®), and radiotherapy followed by surgical resection; a phase II study of radiation therapy, paclitaxel poliglumex and carboplatin in stage III non-small cell lung cancer; and a phase I/II open-label dose escalation study of anti-CTLA4 antibody with radiation for metastatic hormone refractory prostate cancer. Fourth, Dr. Gottschalk is involved with several RTOG (Radiation Therapy Oncology Group) studies. These have included several prostate cancer trials that investigate: high-dose vs standard-dose radiation for intermediate-risk prostate cancer; brachytherapy vs external-beam radiation plus brachytherapy for intermediate-risk prostate cancer; and standard fractionation vs hypofractionation for low-risk prostate cancer. Finally, as Director of the CyberKnife Radiosurgery Program Dr. Gottschalk oversees several of the stereotactic body radiosugery (SBRT) trials for lung and prostate cancer. He has a particular interest in the use of CyberKnife SBRT for the treatment of prostate cancer, kidney cancer, and lung cancer. Dr. Gottschalk also specializes in the treatment of Dupuytren’s and Ledderhose disease using superficial radiation



1988 University of Chicago BA Chemistry
1994 University of Chicago PhD Pathology
1996 University of Chicago MD Medicine
1996-1997 Kaiser Permanente Medical Center, Santa Clara, CA Intern Internal Medicine
1997-2001 UCSF Resident Radiation Oncology
01/00-04/00 UCSF Chief Resident Radiation Oncology
Professional Experience

Professional Experience

2008-Present UCSF Director of the CyberKnife Radiosurgery Program
2008-Present UCSF Associate Professor
2007-2008 UCSF Interim Director of the CyberKnife Radiosurgery Program
2001-2008 UCSF Assistant Professor
1997-2001 UCSF Residency in Radiation Oncology
1996-1997 Kaiser Internal Medicine Internship

Awards & Honors

1984-1988 Dean’s List; National Science Foundation Fellowship for undergraduate research in Chemistry; National Science Foundation Graduate Fellowship, Honorable Mention; Phi Beta Kappa; B.A. with General Honors
1988-1992 NIH Medical Scientist Training Program Fellowship, University of Chicago, Chicago, IL
1992-1994 NIH Training Grant, Department of Molecular Genetic & Cell Biology, University of Chicago, Chicago, IL
1994-1996 Medical Scientist Training Program Fellowship, University of Chicago, Chicago, IL
1998-1999 NIH National Research Service Award, Department of Radiation Oncology, University of California San Francisco
2000 RSNA Research & Education Foundation Roentgen Resident/Fellow Research Award
2001-2002 Clinical Investigator Research Program Recipient, University of California San Francisco
2002 Invited speaker at the Radiation Oncology Young Investigator’s Symposium, Bethesda, MD
2002-2003 UCSF Prostate Cancer SPORE Developmental Research Program Award
2002-2003 Co-investigator on UCSF Prostate Cancer SPORE, Project 3
2003-2005 RSNA Research Scholar Award
2003-2005 ASTRO Junior Faculty Award
2009 ARRO Educator of the year award
2013 Ernest H. Rosenbaum MD Commitment to Patient Care Award
2013 Lawrence Margolis MD Lifetime Teaching Award

Redefining Possible