Jean L. Nakamura, M.D.
Professsor and Vice-Chair
Director of Faculty Development
Department of Radiation Oncology
Scientist, mother, martial arts practitioner
Meet Dr. Nakamura
Dr. Nakamura is a radiation oncologist whose clinical practice focuses on the management of tumors involving the brain and spinal cord. She utilizes multiple state-of-the-art techniques in clinical practice, with a particular emphasis on radiosurgical techniques such as Gamma Knife radiosurgery. Dr. Nakamura received undergraduate and medical degrees from the University of Chicago. She completed an internship in Internal Medicine at the University of Chicago and residency in Radiation Oncology at UCSF. Dr. Nakamura joined the faculty in 2003 and established a clinical practice focusing on neuro-oncology. A physician-scientist, Dr. Nakamura also leads a multi-disciplinary research team focused on cancer genetics, cancer metabolism, radiation susceptibility and drug-resistance. She is an investigator in the UCSF Brain Tumor Center and the UCSF Comprehensive Cancer Center Program Pediatric Malignancies Program. Dr. Nakamura is a recognized expert in radiation-induced malignancies and an investigator in an innovative Specialized Programs of Research Excellence (SPORE) program of the National Cancer Institute (NCI) known as the Developmental and HyperActive Ras Tumor (DHART) SPORE. Her laboratory leads studies investigating cancer susceptibility and the responsible genetic mechanisms. The laboratory utilizes multiple disease models, including glioma, nerve sheath tumors, sarcomas and lung cancers to investigate central mechanisms of genetic and metabolic control of tumorigenesis. A member of multiple national and international committees on cancer research, Dr. Nakamura works with investigators from around the world to advance cancer research and discoveries in the radiation sciences.
Awards & Honors
Significant Research Highlights:
J.L. Nakamura, C. Phong, E. Pinarbasi, S.C. Kogan, S. Vandenberg, A.E. Horvai, B.A. Faddegon, D. Fiedler, K. Shokat, B.T. Houseman, R. Chao, R.O. Pieper, K. Shannon. Dose-dependent effects of focal fractionated irradiation on secondary malignant neoplasms in Nf1 mutant mice. Cancer Res. 2011 Jan 1;71(1):106-15. PMID: 21199799
Mroue, B. Huang, S. Braunstein, A. Firestone, J.L. Nakamura. Loss of the imprinted gene Grb10cooperates with Nf1 loss to promote tumorigenesis. PloS Genetics. 2015 May 22;11(5) PMID: 26000738.
A.L. Sherborne, P.R. Davidson, K. Yu, A.O. Nakamura, R. Mamunur, J.L. Nakamura. Mutational analysis of ionizing radiation-induced neoplasms. Cell Reports 2015 Sep 22;12(11):1915-26. PMID: 26344771
Bhatia, Y. Chen, F.L. Wong, L. Hageman, K. Smith, G. Friedman, J.P. Neglia, M. Arnold, L.M. Turcotte, P. de Blank, G.T. Armstrong, L.L. Robison, D.W. Clapp, K. Shannon, J.L. Nakamura, M.J. Fisher. Subsequent neoplasms after a primary tumor in patients with Neurofibromatosis type I. Journal of Clinical Oncology 2019 Sept 18 PMID: 31532722.