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University of California San Francisco

Our Team

Manju Sharma, Ph.D.

Assistant Professor
Division of Physics
Department of Radiation Oncology

Mother, cynophilist, leisure cooking

Meet Dr. Sharma

I am driven by overcoming challenges in the field and finding new ways to improve the quality of patient care.

Manju Sharma, PhD is an Assistant Professor and the Physics Site Lead at the Mission Bay Campus of the Department of Radiation Oncology at UCSF. She is a ABR Certified Medical Physicist. Dr. Sharma and has previously worked in the Radiation Oncology department at the University of Rochester Medical Center (URMC) where she was an Assistant Professor.
At URMC Dr. Sharma’s work focused on standardization and improvement of brain stereotactic radiation therapy. She has developed software tools for biological modeling of brain metastatic patients.
Dr. Sharma received a Ph.D. in Physics from Panjab University, in India. She got interested in the field of Medical Physics during her stint as a postdoctoral researcher in Radiation Oncology, at the University of Minnesota and Virginia Commonwealth University. She followed her postdoctoral by finishing a CAMPEP Residency from Virginia Commonwealth University

Dr. Sharma’s research interests are in the adaptive radiation therapy and outcome analysis. She is interested in using treatment day patient information to develop adaptive planning strategies and robust optimization methods. She is also interested in pairing biological information in plan adaptation.

Dr. Sharma’s clinical interests are in process mapping and standardization of radiation therapy clinical workflow. She is interested in developing techniques to automate the physics quality assurance processes and easy access to database.



1998-2000 Panjab University, Chandigarh, India MSc Physics
2000-2006 Panjab University, Chandigarh, India PhD Physics
2013-2015 Virginia Commonwealth University Clinical Medical Physics Resident Department of Radiation Oncology
Professional Experience

Professional Experience

2019-present University of California, San Francisco Assistant Professor Radiation Oncology
2015-2019 University of Rochester Medical Center Assistant Professor Radiation Oncology
2010-2013 Virginia Commonwealth University Postdoctoral Fellow Radiation Oncology
2007-2010 University of Minnesota, Minneapolis Postdoctoral Research Associate Therapeutic Radiation Oncology

Awards & Honors

2005 International Travel Award to attend 20th International Conference on X-ray and Inner Shell processes in Melbourne, Australia
2011 Research on optical motion tracking system for total marrow irradiation featured as a research innovation in Medical Physic Web (IOS Publication)
2012 41 Ca pharmakcokinetic model highlighted in 2nd quarterly report of American College of Rheumatology (ACR) as a clinical guideline
2012 Research on dose invariance in adaptive radiation therapy of prostate cancer featured in quarterly newsletter of European Society of Therapeutic Radiology and Oncology (ESTRO)
2013 Research featured as HOT TOPIC in 55th Annual AAPM Meeting-Comparative Efficacy of Image-guided Adaptive Treatment Strategies for Prostate Radiation Therapy via Virtual Clinical Trials



Recent Significant Publications

M Milano, M Sharma, SG Soltys, A Sahgal, KY Usuki, J Grimm, IE Naqa. “Radiation-induced edema after single or multi-fraction stereotactic radiosurgery: A critical review.” Int J of Rad Onc Bio Phys accepted March 101 (2018) 344-357.

M Cummings, P Youn, DP Bergsma, KY Usuki, M Sharma, MC Schell, M Milano. “Single fraction radiosurgery using conservative doses for brain metastases: durable responses in select primaries with limited toxicity. Neurosurgery nyx 427 (2017) 1-8.

C Guy, K Kharki, M Sharma, S Kim, “Clinical investigation of surface dose in flattening-filter-free beams”. J of Clinical Medical Physics 17 (2016) 140-148.

M Sharma, E Fields, D Todor. “A novel two-step optimization scheme for tandem and ovoid (T&O) HDR brachytherapy treatment for locally advanced cervical cancer.” Brachytherapy 14 (2015) 613-618.

H Xu, DJ Vile, M Sharma, JJ Gordon, JV Siebers. “Coverage-based planning to accommodate deformable organ variations in prostate cancer treatment”. Med Phys 41 (2014) 101705.

SK Hui, G Fairchild, L Kidder, M Sharma, M Bhattacharya, S Jackson, C Le, A Petryk, MS Islam, D Yee. “The influence of therapeutic radiation on the patterns of bone remodeling in ovary-intact and ovariectomized mice”. Calcif Tissue Intl, 92 (2013) 372-384.

M Sharma, E Weiss, JV Siebers. “Dose deformation-invariance in adaptive prostate radiation therapy: implication for treatment simulations”. Radiother Oncol 105 (2012) 207-213.

SK Hui, M Sharma and M Bhattacharya. “Liquid scintillator based quantitative measurement of dual radioisotopes (3H and 45Ca) in biological samples for bone remodeling studies”. Applied Radiation Isotopes 70 (1) (2012) 63-68.

SK Hui, G Fairchild, L Kidder, M Sharma, M Bhattacharya, S Johnson, C Le, D Yee. “Skeletal remodeling following clinically relevant radiation-induced bone damage treated with zoledronic acid”. Calcif Tissue Intl 90 (2012) 40-49.

M Sharma, T Santos, N Papanikolopoulos and SK Hui. “On the development of intra-fraction whole body motion tracking during total body irradiation”. J of Biomedical Optics 16 (2011) 1-8.

M Sharma, Z Bajzer and SK Hui. “Development of empirical model using 41Ca for the clinical study of bone remodeling”. J of Clinical Pharmacokinetics 3 (2011) 191-199.

TO Ely, M Sharma, WK Lesniak, B Foster, B Lajos. “Dendrimer nanocomposites as next generation X-ray contrast agents”. Conference, Nanomedicine: Nanotechnology, Biology, and Medicine 3 (2007) 351.


Redefining Possible